The Patented Mediator Release Test (MRT®)

Why MRT® is the Most Complete Blood Test for Food Sensitivities

Despite all of the clinical and immunologic complexities associated with food sensitivities, the single common component of all diet-induced inflammatory reactions is proinflammatory and proalgesic mediator release from white cells. It’s the release of cytokines, histamine, leukotrienes, prostaglandins, etc., from neutrophils, monocytes, eosinophils and lymphocytes that lead to all the negative clinical effects a food sensitivity sufferer endures. This is true under all of the numerous immunologic circumstances and clinical circumstances associated with food sensitivities. Because of the vast array of potential mediators and reacting cells, measuring volumetric changes in all circulating white cells after antigen challenge is the most logical, direct, comprehensive and functional measure of food sensitivity reactions. It simply makes the most sense.

Research on MRT® confirms this. Studies with the University of Miami and research presented at major medical conferences show that MRT® is able to distinguish between symptomatic and asymptomatic populations, that MRT® correlates with inflammation and symptoms, that diets based on MRT® show significant symptom reduction, and that MRT® has excellent real-world reproducibility.

Conversely, a large body of research has shown that elevated mechanisms in food sensitivity, such as food-specific IgG or immune complexes, do not reliably correlate with inflammation or symptoms.

Mediator release is the key event that leads to every negative effect your patients suffer. What matters clinically is that mediator release, and thus an inflammatory response has occurred – not that a potential mechanism is elevated.

This is the clinical value of MRT®. MRT® is a functional measurement of diet-induced sensitivity pathways. MRT® simplifies a highly complex reaction and translates that into the most useable clinical information you can get – quantifying the inflammatory response to foods and food-chemicals.

Not only does MRT® give insight into inflammation provoking foods and food-chemicals, but more importantly MRT® identifies your patient’s BEST foods – the foods that form the basis of their LEAP Eating Plan.

Simply put, MRT® gives you information you can’t get any other way, and that information directly translates into targeted therapy that matters.

MRT® is the foundation of fully addressing food sensitivities and achieving the maximum outcomes in the shortest period of time. This is our goal.


Food Sensitivity

Medical research has shown that food and chemical sensitivities can be involved in many painful symptoms and chronic health problems.

If foods or chemical additives are causing your illness, then medications will only mask the underlying cause and may cause other side effects, and lead to other health problems.

If you haven’t considered food sensitivity as a cause of your symptoms, then you may spend many years unwell, spending money on treatments that won’t work.
The first thing you need to do is to identify your trigger foods/ chemicals. However this is difficult as food reactions may be delayed by hours or days, be dose related (small amounts make no difference but large ones do), vary from person to person, and there are often more than one food you are sensitive to.
The most common blood tests (ELISA, IgG)only help identify type 3 sensitivities which are only 25% of food sensitivity reactions and not food chemicals.

Mediator Release Testing (MRT) tests for both type 3 and type 4 sensitivity pathways and food chemical reactions, to help you quickly overcome even the most troublesome food sensitivity problems. MRT has been independently assessed as the the most accurate and most comprehensive food sensitivity blood test.


Is the MRT accurate?

A blinded peer reviewed scientific study conducted by the Polish Pediatric Association showed MRT to have the highest level of accurancy of any food sensitivty blood test (94.5% sensitivty and 91.8% specificity).

What's the difference between MRT and other food sensitivity tests?

There are a few different tests avaliable to identify food sensitivities. They are IgG, ALCAT and LRA. 

IgG testing: These tests quantify how much IgG you are producing for a specific food, with the assumption that high levels of IgG are only a bad thing. There is a specific type of immune reacdtion called Type 3 Hypersensitivity that can involve IgG or another antibody called IgM. When IgG is involved in triggering mediator release, this testing will be very helpful. Unfortunately, there are three very serious limitations of IgG testing (and why we belive this is not the right test for food sensitivities).

1 - High levels of IgG can be either good (suppressing of an immune response) or bad (causing an immune response). But there is no way to differentiate between good IgG and bad IgG through any of the tests. So you may have a high level of IgG present but this might actually be a good thing.

2 - IgG only plays a minor role in IBS, migraine and fibromyalgia. Instead, research shows that Type 4 Hypersensitvity is the primary type of reaction and Type 4 Hypersensitvity does not involve IgG or any other antibody.

3 - IgG testing cannot identify reactions to checmicals like food additives. It's clearly documented that food chemicals play a very important role in provoking symptoms for many conditions. If you cannot indentify these reactions, you could very well be missing vital information that could impact your health.

How MRT compares to IgG: There are a number of advantages of the MRT over any form of IgG testing. MRT is an endpoint test, meaning that all the adverse reactions end up causing mediator release. So the MRT does this without caring about the mechanism. In fact the MRT is able to take into account the actions of all mechanisms, whether they are anitbodies or other, because all of them ultimately will cause white blood cells to release mediators. MRT is able to account for a much wider array of reactions than the reltively simple IgG testing. In addition, MRT is able to identify reactions to chemicals. Overall the MRT is unequivocally more accurate and useful clinically than IgG testing.